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Newly discovered molecules show promise in eradicating cancer stem cells

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Newly discovered molecules show promise in eradicating cancer stem cells

Effective management of advanced cancer requires systematic treatment, including small molecules that target unique features of aggressive tumor cells. In the meantime, tumors are heterogeneous and current proof proposes that a subpopulation of tumor cells, called tumor-initiating or cancer stem cells, are responsible for metastatic dissemination, tumor relapse, and conceivably drug resistance. Classical apoptotic drugs are less effective against this critical subpopulation. In the course of generating a library of open-chain epothilones, scientists investigating improvements to a commonly used chemotherapy drug have discovered a new class of small molecule anticancer agents that show promise in eradicating cancer stem cells. Most fascinating...

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